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The efficacy of paroxetine in prevention anxiety and impotence patients with following spinal cord injury was evaluated in three studies. The study of five patients who experienced sexual dysfunction post-spinal cord injury showed that paroxetine improved erectile function (p less than 0.01). The study of five patients who experienced decreased sexual desire and inability to get sustain an erection showed no significant difference between paroxetine and placebo. The study of 21 patients with generalized anxiety disorder showed that paroxetine reduced anxiety and helped to prevent relapse in the following 12 weeks. study of four patients with anxiety disorder and one dysthymia on placebo showed that paroxetine also reduced both anxiety and dysthymia improved their sexual satisfaction and arousal reported that paroxetine improved sexual function of all patients.
Clinical efficacy of bupropion 20 mg and extended release in the prevention of impotence absence sexual dysfunction following spinal cord injury. Bupropion 20 mg and extended release reduced impotence in the presence of sexual dysfunction.
This was a 12-week randomized, double-blind, placebo-controlled study in patients with impotence following spinal cord injury. The average age was 36±8, and the mean duration of dysfunction was 5±4 years. At post-treatment, sexual dysfunction was present in eight patients (15%), and bupropion reduced impotence in six of those patients. Impotence and improved sexual function were maintained through 12 best drugstore bb cream in canada weeks. Bupropion did not cause serious adverse events in the trial.
A single-blind, multicenter, active-controlled, double-blind randomized trial was conducted to determine whether bupropion is able to reduce sexual dysfunction and improve function following spinal cord injury. Patients were randomly assigned to one of four groups (n=16 each): no treatment (placebo group), bupropion, placebo + bupropion (titrated bupropion), or placebo + placebo). Participants in the bupropion + placebo group showed significantly improved sexual function compared to their baseline values following trial assignment, with sexual dysfunction present in one and increased sexual function in the other two groups (p less than 0.001 (see also Table 2). Additionally, sexual dysfunction and decreased desire satisfaction both significantly in the bupropion + placebo group (p less than 0.001 (see also Table 3). Both titratations resulted in significant reductions sexual dysfunction throughout the trial (p less than 0.01 and p 0.001). Improvements in sexual function occurred despite not being adherent to medication, even in the titration phases, end point for which was not assessed (see Data Collection and Analysis).
Studies (including one large study) were funded by the manufacturers of paroxetine and bupropion at the time they became available in the US mid 1990s.
Bupropion is an antidepressant with a longer duration of action (3 months) than paroxetine. Its mechanism of action is known to be via reducing the levels of monoamines and associated histaminergic activity in the CNS.
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